Detection of doxorubicin-induced apoptosis of leukemic T-lymphocytes by laser tweezers Raman spectroscopy

@inproceedings{Moritz2010DetectionOD,
  title={Detection of doxorubicin-induced apoptosis of leukemic T-lymphocytes by laser tweezers Raman spectroscopy},
  author={Tobias J. Moritz and Douglas S. Taylor and Denise M. Krol and John Fritch and James W Chan},
  booktitle={Biomedical optics express},
  year={2010}
}
  • Tobias J. Moritz, Douglas S. Taylor, +2 authors James W Chan
  • Published in Biomedical optics express 2010
  • Computer Science, Medicine
  • Laser tweezers Raman spectroscopy (LTRS) was used to acquire the Raman spectra of leukemic T lymphocytes exposed to the chemotherapy drug doxorubicin at different time points over 72 hours. Changes observed in the Raman spectra were dependent on drug exposure time and concentration. The sequence of spectral changes includes an intensity increase in lipid Raman peaks, followed by an intensity increase in DNA Raman peaks, and finally changes in DNA and protein (phenylalanine) Raman vibrations… CONTINUE READING

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