Detection of distinct glycosylation patterns on human γ-glutamyl transpeptidase 1 using antibody-lectin sandwich array (ALSA) technology

@inproceedings{West2014DetectionOD,
  title={Detection of distinct glycosylation patterns on human γ-glutamyl transpeptidase 1 using antibody-lectin sandwich array (ALSA) technology},
  author={Matthew Blaine West and Katie Partyka and Christa L. Feasley and Kevin A. Maupin and Indiwari Goppallawa and Christopher M West and Brian B. Haab and Marie H. Hanigan},
  booktitle={BMC biotechnology},
  year={2014}
}
BACKGROUND γ-Glutamyl transpeptidase 1 (GGT1) is an N-glycosylated membrane protein that catabolizes extracellular glutathione and other γ-glutamyl-containing substrates. In a variety of disease states, including tumor formation, the enzyme is shed from the surface of the cell and can be detected in serum. The structures of the N-glycans on human GGT1 (hGGT1) have been shown to be tissue-specific. Tumor-specific changes in the glycans have also been observed, suggesting that the N-glycans on… CONTINUE READING
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