Detection of differentially methylated regions from whole-genome bisulfite sequencing data without replicates

@article{Wu2015DetectionOD,
  title={Detection of differentially methylated regions from whole-genome bisulfite sequencing data without replicates},
  author={Hao Wu and Tianlei Xu and Hao Feng and Li Chen and Ben Li and Bing Yao and Zhaohui S. Qin and Peng Jin and Karen N. Conneely},
  journal={Nucleic Acids Research},
  year={2015},
  volume={43},
  pages={e141 - e141}
}
DNA methylation is an important epigenetic modification involved in many biological processes and diseases. Recent developments in whole genome bisulfite sequencing (WGBS) technology have enabled genome-wide measurements of DNA methylation at single base pair resolution. Many experiments have been conducted to compare DNA methylation profiles under different biological contexts, with the goal of identifying differentially methylated regions (DMRs). Due to the high cost of WGBS experiments, many… 

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