Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor

@article{Zhang2001DetectionOD,
  title={Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor},
  author={Zhonghua Zhang and Raymond N. Dubois},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={4450-4456}
}
Numerous reports suggest that use of nonsteroidal anti-inflammatory drugs (NSAIDs) decrease mortality from colorectal cancer. To better understand all of the mechanisms underlying this effect, the global pattern of gene expression in colon carcinoma cells following treatment with NS-398, a selective cyclo-oxygenase-2 inhibitor was evaluated. We utilized suppression subtractive hybridization combined with differential screening to identify genes whose expression was affected following treatment… CONTINUE READING