Detection of different forms of variant transthyretin (Met30) in cerebrospinal fluid

@article{Ando1997DetectionOD,
  title={Detection of different forms of variant transthyretin (Met30) in cerebrospinal fluid},
  author={Y Ando and Ole Bernt Suhr and Taro Yamashita and Per-Ingval Ohlsson and Masayuki Shinjuku-ku Ando},
  journal={Neuroscience Letters},
  year={1997},
  volume={238},
  pages={123-126}
}
To detect the variant transthyretin (TTR; Met30) in cerebrospinal fluid (CSF) of familial amyloidotic polyneuropathy (FAP) patients, we have applied a new method using a centrifugal concentrator device and electrospray ionization mass spectrometry (ESI-MS). Only 100 microl of CSF and 30 microl of the antibody for TTR was needed for the analysis. After preparation of the samples with anti-TTR antibody, they were passed through a 1000 kDa cut-off centrifugal concentrator which retained the… CONTINUE READING
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