Detection of deep venous thrombi and pulmonary embolus with technetium-99m-DD-3B6/22 anti-fibrin monoclonal antibody Fab' fragment.

@article{Bautovich1994DetectionOD,
  title={Detection of deep venous thrombi and pulmonary embolus with technetium-99m-DD-3B6/22 anti-fibrin monoclonal antibody Fab' fragment.},
  author={George J. Bautovich and Socrates Angelides and Fook Thean Lee and Robert Greenough and Peter G. Bundesen and Paraic Murray and Peter Schmidt and R. Miles Waugh and Jeanette L Harris and K P Cameron},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1994},
  volume={35 2},
  pages={195-202}
}
UNLABELLED Technetium-99m-labeled anti-fibrin DD-3B6/22 Fab' monoclonal antibody fragments, which specifically target human cross-linked fibrin with high affinity, were evaluated in humans for safety and their capacity to detect deep vein thrombi and pulmonary embolism. METHODS Twenty patients with proven deep-vein thrombosis, documented by contrast venography, or venous duplex scan, were injected with a 600 MBq (0.5 mg) dose of antibody. Planar images of the lower limbs were recorded at 0, 2… CONTINUE READING