Detection of cystic fibrosis homozygotes and heterozygotes by serum isoelectrofocusing

@article{Nevin1981DetectionOC,
  title={Detection of cystic fibrosis homozygotes and heterozygotes by serum isoelectrofocusing},
  author={Gerald B Nevin and Norman Cumming Nevin and Aileen O B Redmond and I. R. Young and G Walter Tully},
  journal={Human Genetics},
  year={1981},
  volume={56},
  pages={387-389}
}
It is suggested that the majority of individuals with the cystic fibrosis (CF) gene have a unique serum protein (CFP) which can be demonstrated by means of isoelectrofocusing (IEF) in thin layer polyacrylamide gels. We have found the CFP in 90% of patients with cystic fibrosis, in approximately 80% of individuals heterozygous for the CF gene, and in 8% of normal control individuals. We conclude that CFP is a useful marker for the CF gene.