Detection of cysteine- and lysine-based protein adductions by reactive metabolites of 2,5-dimethylfuran.

Abstract

Many furan-containing compounds are known to be toxic and/or carcinogenic. Metabolic activation of toxic furans to cis-enediones (cis-enedials or γ-ketoenals) is generally considered as the initial step towards the processes of their toxicities. Sequential modification of key proteins by the electrophilic reactive intermediates is suggested to be an… (More)
DOI: 10.1016/j.aca.2015.09.017

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Cite this paper

@article{Wang2015DetectionOC, title={Detection of cysteine- and lysine-based protein adductions by reactive metabolites of 2,5-dimethylfuran.}, author={Kai Wang and Weiwei Li and Jiaming Chen and Ying Peng and Jiang Zheng}, journal={Analytica chimica acta}, year={2015}, volume={896}, pages={93-101} }