Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats

@article{Allchorne2005DetectionOC,
  title={Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats},
  author={Andrew J. Allchorne and Daniel C. Broom and Clifford J Woolf},
  journal={Molecular Pain},
  year={2005},
  volume={1},
  pages={36 - 36}
}
BACKGROUND Pain is elicited by cold, and a major feature of many neuropathic pain states is that normally innocuous cool stimuli begin to produce pain (cold allodynia). To expand our understanding of cold induced pain states we have studied cold pain behaviors over a range of temperatures in several animal models of chronic pain. RESULTS We demonstrate that a Peltier-cooled cold plate with +/- 1 degrees C sensitivity enables quantitative measurement of a detection withdrawal response to cold… CONTINUE READING
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