Detection of circulating neoplastic cells by reverse-transcriptase polymerase chain reaction in malignant melanoma: association with clinical stage and prognosis.

@article{Mellado1996DetectionOC,
  title={Detection of circulating neoplastic cells by reverse-transcriptase polymerase chain reaction in malignant melanoma: association with clinical stage and prognosis.},
  author={Bego{\~n}a Mellado and Dolors Colomer and Teresa Castel and Montserrat Mu{\~n}oz and Esperanza Carballo and Maica Gal{\'a}n and Jos{\'e} Manuel Mascar{\'o} and J L Vives-Corrons and Juan Jos{\'e} Grau and Jordi Vila Estape},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1996},
  volume={14 7},
  pages={2091-7}
}
PURPOSE Circulating melanoma cells can be detected in peripheral blood by means of tyrosinase mRNA amplification by reverse-transcriptase polymerase chain reaction (RT-PCR). We conducted a prospective study to evaluate the clinical significance of the presence of circulating neoplastic cells in the blood of patients with malignant melanoma (MM). METHODS A sensitive RT-PCR assay was used to detect tyrosinase mRNA in the peripheral blood of patients with stages I to IV melanoma. Healthy… CONTINUE READING

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