Detection of circulating methylated opioid binding protein/cell adhesion molecule-like gene as a biomarker for ovarian carcinoma.

@article{Zhou2014DetectionOC,
  title={Detection of circulating methylated opioid binding protein/cell adhesion molecule-like gene as a biomarker for ovarian carcinoma.},
  author={Feng Zhou and Min Ma and Guohua Tao and Xiang Chen and Wei Xie and Ying Wang and Xingjian Cao},
  journal={Clinical laboratory},
  year={2014},
  volume={60 5},
  pages={759-65}
}
BACKGROUND Hypermethylation of the opioid binding protein/cell adhesion molecule-like (OPCML) gene is frequently observed in ovarian carcinoma. We evaluated the detection of circulating hypermethylated OPCML for detecting ovarian carcinoma and assessing its prognosis. METHODS We studied 85 tissue samples including 45 ovarian cancer tissues and 40 normal ovarian tissues and blood samples from 45 ovarian cancer patients and 20 healthy individuals. Bisulfite sequencing and methylation-sensitive… CONTINUE READING

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