Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases.

@article{Tsujisaki1991DetectionOC,
  title={Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases.},
  author={Masayuki Tsujisaki and Kazue Imai and Hideki Hirata and Yoshinori Hanzawa and Jiro Masuya and Takahide Nakano and Takayuki Sugiyama and Masashi Matsui and Yuji Hinoda and Akira Yachi},
  journal={Clinical and experimental immunology},
  year={1991},
  volume={85 1},
  pages={3-8}
}
A new monoclonal antibody (MoAb) HA58 (IgG1) was prepared, which recognizes the binding site on the intercellular adhesion molecule-1 (ICAM-1) antigen to the lymphocyte function-associated antigen-1 (LFA-1). The double-determinant immunoassay (DDIA) was established with use of MoAb HA58 and another anti-ICAM-1, MoAb CL207, to detect the soluble, shedding ICAM-1 antigen. Human recombinant interferon-gamma (IFN-gamma) induced not only the expression of cell surface ICAM-1, but also the shedding… CONTINUE READING

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