Detection of circulating cytokeratin-positive cells in the blood of breast cancer patients using immunomagnetic enrichment and digital microscopy.

@article{Witzig2002DetectionOC,
  title={Detection of circulating cytokeratin-positive cells in the blood of breast cancer patients using immunomagnetic enrichment and digital microscopy.},
  author={Thomas E Witzig and Blaise Bossy and Teresa K. Kimlinger and Patrick C. Roche and James N. Ingle and Clive S. Grant and John Donohue and Vera J. Suman and Douglas C Harrington and Jose Torre-Bueno and Kenneth D. Bauer},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 5},
  pages={1085-91}
}
PURPOSE To examine the feasibility for identifying and enumerating cytokeratin positive (CK+) cells in the peripheral blood of breast cancer patients. EXPERIMENTAL DESIGN Blood specimens from 34 normal donors (negative controls), 15 samples to which carcinoma cells were added (positive controls), and 84 breast cancer patients [27 node-negative (N-), 29 node-positive (N+), and 28 metastatic] were studied. RBCs were lysed with ammonium chloride and the resulting cell suspension incubated with… CONTINUE READING

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