The aim of this study was to examine the immune response to MAA adducts and other aldehyde adducts during long - term ethanol exposure .
Detection of circulating antibodies to malondialdehyde - acetaldehyde adducts in ethanol - fed rats .
Malondialdehyde and acetaldehyde react together with proteins and form hybrid protein conjugates designated as MAA adducts , which have been detected in livers of ethanol - fed rats .
Rats were pair - fed for 7 months with a liquid diet containing either ethanol or isocaloric carbohydrate . Circulating antibody titers against MAA adducts and acetaldehyde adducts
Antibody titers to reduced and nonreduced acetaldehyde adducts were very low , and no significant differences were observed between ethanol - fed and control animals .