Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84

@article{Cremer1986DetectionOC,
  title={Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84},
  author={Thomas Cremer and J. Landegent and Andrea Br{\"u}ckner and Hendrik P. N. Scholl and Margit Schardin and H. D. Hager and Peter Devilee and Peter Pearson and M. van der Ploeg},
  journal={Human Genetics},
  year={1986},
  volume={74},
  pages={346-352}
}
The localization of chromosome 18 in human interphase nuclei is demonstrated by use of radioactive and nonradioactive in situ hybridization techniques with a DNA clone designated L1.84. This clone represents a distinct subpopulation of the repetitive human alphoid DNA family, located in the centric region of chromosome 18. Under stringent hybridization conditions hybridization of L1.84 is restricted to chromosome 18 and reflects the number of these chromosomes present in the nuclei, namely, two… CONTINUE READING
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