Detection of chromosomal imbalances in retinoblastoma by matrix‐based comparative genomic hybridization

  title={Detection of chromosomal imbalances in retinoblastoma by matrix‐based comparative genomic hybridization},
  author={B. Zielinski and S. Gratias and G. Toedt and F. Mendrzyk and D. Stange and B. Radlwimmer and D. Lohmann and P. Lichter},
  • B. Zielinski, S. Gratias, +5 authors P. Lichter
  • Published 2005
  • Biology, Medicine
  • Genes
  • The genetic hallmark of retinoblastoma is mutation or deletion of the RB1 gene, whereas other genetic alterations that are also required are largely unknown. To screen for genomic imbalances on a genomewide level, we studied a series of 17 primary retinoblastomas by matrix‐based comparative genomic hybridization (matrix‐CGH). The matrix‐CGH chip contained 6,000 immobilized genomic DNA fragments covering the human genome, with an average resolution of about 500 kb. The most frequent imbalances… CONTINUE READING
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