Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing.

@article{Leary2012DetectionOC,
  title={Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing.},
  author={Rebecca J. Leary and M. T. Sausen and Isaac Kinde and Nickolas Papadopoulos and John D. Carpten and David Craig and Joyce O'Shaughnessy and Kenneth W. Kinzler and Giovanni Parmigiani and Bert Vogelstein and Luis A Diaz and Victor E. Velculescu},
  journal={Science translational medicine},
  year={2012},
  volume={4 162},
  pages={162ra154}
}
Clinical management of cancer patients could be improved through the development of noninvasive approaches for the detection of incipient, residual, and recurrent tumors. We describe an approach to directly identify tumor-derived chromosomal alterations through analysis of circulating cell-free DNA from cancer patients. Whole-genome analyses of DNA from the plasma of 10 colorectal and breast cancer patients and 10 healthy individuals with massively parallel sequencing identified, in all… CONTINUE READING
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