Detection of chemical-induced unscheduled DNA synthesis in cultures of normal adult human keratinocytes.

@article{Lawrence1991DetectionOC,
  title={Detection of chemical-induced unscheduled DNA synthesis in cultures of normal adult human keratinocytes.},
  author={Joyce Lawrence and Diane J. Benford},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={1991},
  volume={5 5-6},
  pages={377-81}
}
Human keratinocytes are the most appropriate target cells to employ in an in vitro model to study the potential ability of a chemical to react with the genome of human skin cells. The resulting damage to DNA may be a key initiating factor in the subsequent development of squamous epithelial carcinoma, which is a common form of cancer in humans… CONTINUE READING