Detection of cell-drug (hapten)-antibody complexes by the gel test.

@article{Salama1992DetectionOC,
  title={Detection of cell-drug (hapten)-antibody complexes by the gel test.},
  author={Abdulagabar Salama and H Bergh{\"o}fer and C. Mueller-Eckhardt},
  journal={Transfusion},
  year={1992},
  volume={32 6},
  pages={554-6}
}
Most drugs causing immunocytopenias do not bind firmly to the affected cells. Consequently, the drug-dependent antibodies in such cases are completely removed from their binding sites by conventional cell washing. It has recently been shown that such cell-drug-antibody complexes do survive the washing procedure, if the drug (metabolite) was included in the wash medium. The study reported here used the microtube gel test to reexamine the reactivity of different drug-dependent red cell antibodies… CONTINUE READING

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