Detection of cartilage matrix degradation by autofluorescence lifetime.

  title={Detection of cartilage matrix degradation by autofluorescence lifetime.},
  author={Hugh B Manning and Mohammad B Nickdel and Kazuhiro Yamamoto and Jo{\~a}o L Lagarto and Douglas J. Kelly and Clifford B. Talbot and Gordon T Kennedy and Jayesh Dudhia and John Lever and Christopher Dunsby and Paul R. French and Yoshifumi Itoh},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  volume={32 1},
Cartilage is a vital organ to maintain joint function. Upon arthritis, proteolytic enzymes initiate degradation of cartilage extracellular matrix (ECM) resulting in eventual loss of joint function. However, there are only limited ways of non-invasively monitoring early chemical changes in cartilage matrix. Here we report that the autofluorescence decay… CONTINUE READING