Detection of cancer-specific markers amid massive mass spectral data.

  title={Detection of cancer-specific markers amid massive mass spectral data.},
  author={Wei Zhu and Xuena Wang and Yeming Ma and Manlong Rao and James Glimm and John S. Kovach},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 25},
We propose a comprehensive pattern recognition procedure that will achieve best discrimination between two or more sets of subjects with data in the same coordinate system. Applying the procedure to MS data of proteomic analysis of serum from ovarian cancer patients and serum from cancer-free individuals in the Food and Drug Administration/National Cancer Institute Clinical Proteomics Database, we have achieved perfect discrimination (100% sensitivity, 100% specificity) of patients with ovarian… CONTINUE READING
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