Detection of brain tumor cells in the peripheral blood by a telomerase promoter-based assay.

@article{MacArthur2014DetectionOB,
  title={Detection of brain tumor cells in the peripheral blood by a telomerase promoter-based assay.},
  author={Kelly M MacArthur and Gary D. Kao and Sanjay Chandrasekaran and Michelle Alonso-Basanta and Christina Hunter Chapman and Robert A Lustig and E. Paul Wileyto and Stephen M. Hahn and Jay F. Dorsey},
  journal={Cancer research},
  year={2014},
  volume={74 8},
  pages={
          2152-9
        }
}
Blood tests to detect circulating tumor cells (CTC) offer great potential to monitor disease status, gauge prognosis, and guide treatment decisions for patients with cancer. For patients with brain tumors, such as aggressive glioblastoma multiforme, CTC assays are needed that do not rely on expression of cancer cell surface biomarkers like epithelial cell adhesion molecules that brain tumors tend to lack. Here, we describe a strategy to detect CTC based on telomerase activity, which is elevated… 

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