Detection of bovine spongiform encephalopathy, ovine scrapie prion-related protein (PrPSc) and normal PrPc by monoclonal antibodies raised to copper-refolded prion protein.

@article{Thackray2003DetectionOB,
  title={Detection of bovine spongiform encephalopathy, ovine scrapie prion-related protein (PrPSc) and normal PrPc by monoclonal antibodies raised to copper-refolded prion protein.},
  author={Alana M Thackray and J. Y. Madec and Edmond Wong and Robert J. Morgan-Warren and David R Brown and Thierry Baron and Raymond Bujdoso},
  journal={The Biochemical journal},
  year={2003},
  volume={370 Pt 1},
  pages={81-90}
}
Prion-related protein (PrP) is a glycosylphosphatidylinositol-linked cell-surface protein expressed by a wide variety of cells, including those of the nervous system and the immune system. Several functions of normal cellular PrP (PrPc) have been proposed that may be associated with the capacity of this protein to bind copper. In the present study, we describe the generation of a panel of monoclonal antibodies raised to copper-refolded PrP, which may be used to analyse the normal and disease… CONTINUE READING