Detection of blast-related traumatic brain injury in U.S. military personnel.

@article{MacDonald2011DetectionOB,
  title={Detection of blast-related traumatic brain injury in U.S. military personnel.},
  author={Christine L. Mac Donald and Ann M. Johnson and Dana Cooper and Elliot C. Nelson and Nicole J Werner and Joshua S. Shimony and Abraham Z. Snyder and Marcus E. Raichle and John R Witherow and Raymond Fang and Stephen Flaherty and David L. Brody},
  journal={The New England journal of medicine},
  year={2011},
  volume={364 22},
  pages={
          2091-100
        }
}
BACKGROUND Blast-related traumatic brain injuries have been common in the Iraq and Afghanistan wars, but fundamental questions about the nature of these injuries remain unanswered. METHODS We tested the hypothesis that blast-related traumatic brain injury causes traumatic axonal injury, using diffusion tensor imaging (DTI), an advanced form of magnetic resonance imaging that is sensitive to axonal injury. The subjects were 63 U.S. military personnel who had a clinical diagnosis of mild… Expand
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Animal models that reliably demonstrate clinically relevant endpoints will expedite development of new treatments, diagnostics, preventive measures, and rehabilitative strategies for individuals affected by blast TBI and its aftermath. Expand
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TLDR
The epidemiological, neuropathologic, and mechanistic characteristics of blast traumatic brain injury specific to the military population, and underreported injury in service members with significant neurological and cognitive impacts are reviewed. Expand
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TLDR
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White matter abnormalities in blast mild traumatic brain injury in the military
ABSTRACT Mild traumatic brain injury (mTBI) has been labeled the “signature injury” of the wars in Iraq and Afghanistan, and approximately half of mTBIs that occur in combat are due to explosiveExpand
Military-related traumatic brain injury and neurodegeneration
TLDR
Early changes of chronic traumatic encephalopathy are found in four young veterans of the Iraq and Afghanistan conflict who were exposed to explosive blast and in another young veteran who was repetitively concussed. Expand
Traumatic Brain Injury in Combat Trauma
TLDR
The etiology and manifestations of combat-related traumatic brain injuries are reviewed with further discussion of acute management and aeromedical evacuation in the deployed setting. Expand
Clinical relevance of blast-related traumatic brain injury
TLDR
The recently published results by Mac Donald and colleagues have created a sense of cautious optimism regarding the use of diffusion tensor imaging (DTI) in detecting structural brain damage in blast-exposed patients suffering from mild TBI. Expand
A mouse model of blast-induced mild traumatic brain injury
TLDR
Cellular and biochemical studies are underway in order to further correlate the blast-induced cognitive and behavioral changes and to identify possible underlying mechanisms that may help develop treatment- and neuroprotective modalities. Expand
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