# Detection of biological signals from a live mammalian muscle using an early stage diamond quantum sensor

@article{Webb2020DetectionOB,
title={Detection of biological signals from a live mammalian muscle using an early stage diamond quantum sensor},
author={James L. Webb and Luca Troise and Nikolaj Winther Hansen and Christoffer Olsson and Adam M. Wojciechowski and Jocelyn Achard and O. Brinza and Robert Staacke and Michael Kieschnick and Jan Meijer and Axel Thielscher and Jean-François Perrier and Kirstine Berg-S{\o}rensen and Alexander Huck and Ulrik Lund Andersen},
journal={Scientific Reports},
year={2020},
volume={11}
}
• Published 3 August 2020
• Materials Science
• Scientific Reports
The ability to perform noninvasive and non-contact measurements of electric signals produced by action potentials is essential in biomedicine. A key method to do this is to remotely sense signals by the magnetic field they induce. Existing methods for magnetic field sensing of mammalian tissue, used in techniques such as magnetoencephalography of the brain, require cryogenically cooled superconducting detectors. These have many disadvantages in terms of high cost, flexibility and limited…
10 Citations
• Biology
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This work records biomagnetic induced by ionic currents in mouse corpus callosum axons without direct sample interaction, accurately recovering signals corresponding to action potential propagation while demonstrating in situ pharmacology during biomagnetic recording through tetrodotoxin inhibition of voltage gated sodium channels.
• Biology
• 2021
The sensor is capable of recording localized neuromuscular activity from the laser stimulation site without photovoltaic or fluorescence artifacts associated with alternative techniques, and represents an important step towards selective induction of localized neurobiological activity while performing passive sensing and imaging with diamond sensors.
• Physics
• 2020
We present an innovative experimental set-up that uses Nitrogen-Vacancy centres in diamonds to measure magnetic fields with the sensitivity of η = 68 ± 3 nT / Hz \$\eta =68\pm
• Medicine
Communications Physics
• 2022
The acquired magnetic images indicate that the cardiac signal source is well explained by vertically distributed current dipoles, pointing from the right atrium base via the Purkinje fibre bundle to the left ventricular apex, which is consistent with and complementary to an alternative picture of electric current density distribution calculated with a stream function method.
• Biology, Physics
• 2022
The topic of biomagnetic recordings on animal models using optically pumped magnetometers is reviewed, and experiments on detecting nerve impulses in the frog sciatic nerve and the heart beat in an isolated guinea pig heart are presented.
• Biology
Frontiers in Neuroscience
• 2021
The present simulation study predicts that high-resolution magnetic imaging of the action potentials traveling along the auditory brainstem pathway will only be possible for next generation NV sensors, however, the existing sensors already have sufficient sensitivity to support the magnetic sensing of cumulated neural signals sampled from larger parts of the pathway, which might be a promising intermediate step toward further maturing this novel technology.
• Physics
Scientific reports
• 2022
Wide field-of-view magnetic field microscopy has been realised by probing shifts in optically detected magnetic resonance (ODMR) spectrum of Nitrogen Vacancy (NV) defect centers in diamond. However,
• Physics
• 2022
Localized electronic spins in solid-state environments form versatile and robust platforms for quantum sensing, metrology and quantum information processing. With optically detected magnetic
• Physics
Physical Review Applied
• 2022
Quantum sensors based on spin defect ensembles have seen rapid development in recent years, with a wide array of target applications. Historically, these sensors have used optical methods to prepare
• Physics
Review of Scientific Instruments
• 2023
We present a new magnetometry method integrating an ensemble of nitrogen-vacancy (NV) centers in a single-crystal diamond with an extended dynamic range for monitoring a fast changing magnetic-field.

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Sensing of signals from biological processes such as action potential propagation in nerves, are essential for clinical diagnosis and basic understanding of physiology. Sensing can be performed
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Scientific reports
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Scientific Reports
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Scientific Reports
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A novel approach for wide-field imaging of the neural network dynamics of brain slices that uses highly sensitivity magnetometry based on nitrogen-vacancy (NV) centers in diamond and compares the imaging of neural slice activity with that of a single planar pyramidal cell is suggested.
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