Detection of beta-blockers in urine by solid-phase extraction-supercritical fluid extraction and gas chromatography-mass spectrometry.

@article{Hartonen1996DetectionOB,
  title={Detection of beta-blockers in urine by solid-phase extraction-supercritical fluid extraction and gas chromatography-mass spectrometry.},
  author={Kari Hartonen and Marja-Liisa Riekkola},
  journal={Journal of chromatography. B, Biomedical applications},
  year={1996},
  volume={676 1},
  pages={
          45-52
        }
}
The most convenient way to perform supercritical fluid extraction (SFE) of liquid sample matrices is to combine it with solid-phase extraction (SPE). beta-Blockers from urine were collected on an Empore disc, which was then placed into an extraction cell for derivatization and SFE. SPE recovery was best at pH 10. Effects of temperature, pressure and volume of pyridine on the acetylation and SFE processes were studied. Without acetylation the beta-blockers were not significantly soluble in CO2… CONTINUE READING
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