Detection of apoptotic cells in archival tissue from diffuse astrocytomas using a monoclonal antibody to single-stranded DNA.

@article{Korkolopoulou2001DetectionOA,
  title={Detection of apoptotic cells in archival tissue from diffuse astrocytomas using a monoclonal antibody to single-stranded DNA.},
  author={Penelope Korkolopoulou and Anastasia Konstantinidou and Efstratios S. Patsouris and Panagiotis N Christodoulou and Eupthemia Thomas-Tsagli and Panagiotis S. Davaris},
  journal={The Journal of pathology},
  year={2001},
  volume={193 3},
  pages={
          377-82
        }
}
Precise quantitation of apoptotic cells in gliomas is necessary to determine the role of apoptosis in tumour growth, prognosis, and treatment. This study investigated the incidence of baseline apoptosis in relation to proliferation status, p53 expression, standard clinicopathological parameters, and outcome, in a series of 61 patients with diffuse cerebral astrocytomas. Apoptotic fractions were quantified immunohistochemically by means of a novel monoclonal antibody recognizing exposed single… CONTINUE READING
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