Detection of antineutrophil cytoplasmic antibodies (ANCAs): a multicentre European Vasculitis Study Group (EUVAS) evaluation of the value of indirect immunofluorescence (IIF) versus antigen-specific immunoassays.

@article{Damoiseaux2017DetectionOA,
  title={Detection of antineutrophil cytoplasmic antibodies (ANCAs): a multicentre European Vasculitis Study Group (EUVAS) evaluation of the value of indirect immunofluorescence (IIF) versus antigen-specific immunoassays.},
  author={Jan Damoiseaux and Elena Csernok and Niels Kristian Rasmussen and Frank Moosig and Pieter van Paassen and Bo Baslund and Pieter Vermeersch and Daniel Blockmans and Jan-Willem Cohen Tervaert and Xavier Bossuyt},
  journal={Annals of the rheumatic diseases},
  year={2017},
  volume={76 4},
  pages={647-653}
}
OBJECTIVE This multicentre study was performed to evaluate the diagnostic accuracy of a wide spectrum of novel technologies nowadays available for detection of myeloperoxidase (MPO) and proteinase 3 (PR3)-antineutrophil cytoplasmic antibodies (ANCAs). METHODS Sera (obtained at the time of diagnosis) from 251 patients with ANCA-associated vasculitis (AAV), including granulomatosis with polyangiitis and microscopic polyangiitis, and from 924 disease controls were tested for the presence of… CONTINUE READING
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