Detection of anti-erythropoietin antibodies in haemodialysis patients treated with recombinant human-erythropoietin.

@article{Castelli2000DetectionOA,
  title={Detection of anti-erythropoietin antibodies in haemodialysis patients treated with recombinant human-erythropoietin.},
  author={Giampaolo Castelli and A. Famularo and Claudia Semino and Anna Maria Mach{\'i} and Adriana Ceci and G. Cannella and Giovanni Melioli},
  journal={Pharmacological research},
  year={2000},
  volume={41 3},
  pages={
          313-8
        }
}
An enzyme-immunoassay was developed to evaluate the presence of anti-erythropoietin antibodies in plasma samples obtained from renal failure patients treated with recombinant human erythropoietin (rh-EPO). The assay was specific and reproducible. Normal donors had no antibodies to EPO, while 67% of treated patients were positive to the assay. While the specificity of anti-EPO IgG antibodies was high, their affinity for the antigen was low. This finding can be explained by the very small… CONTINUE READING
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