Detection of anti-Nogo receptor autoantibody in the serum of multiple sclerosis and controls.

@article{Onoue2007DetectionOA,
  title={Detection of anti-Nogo receptor autoantibody in the serum of multiple sclerosis and controls.},
  author={Hiroyuki Onoue and J Satoh and Motohiko Ogawa and Hiroko Tabunoki and Takashi Yamamura},
  journal={Acta neurologica Scandinavica},
  year={2007},
  volume={115 3},
  pages={153-60}
}
OBJECTIVES A myelin-associated neurite outgrowth inhibitor Nogo-A plays a key role in inhibition of axonal regeneration. Axonal damage beginning at the early stage of multiple sclerosis (MS) is responsible for permanent neurological deficits, although its molecular mechanism remains unknown. The aim was to study the prevalence of autoantibodies against Nogo-A and Nogo receptor (NgR) in the serum of MS. METHODS The antibodies were identified in the serum of 30 MS patients, 22 patients with non… CONTINUE READING