Detection of an intrinsic marker in hypoxic cells.

  title={Detection of an intrinsic marker in hypoxic cells.},
  author={Lynn Hlatky and C. S. Ring and Rainer K. Sachs},
  journal={Cancer research},
  volume={49 18},
An autoradiographic method is presented for detecting, within a cell population, those cells which have been subjected to chronic hypoxia. No radioisotope is administered; rather the photographic emulsion is chemically reduced by intrinsic constituents of the cells. Hypoxic regions in the sandwich system, a multicellular in vitro tumor model, were detected in this manner. These regions were then compared with hypoxic sandwich regions as demonstrated by [3H]misonidazole labeling. Auxiliary… CONTINUE READING

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