Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V.

@article{Kuypers1996DetectionOA,
  title={Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V.},
  author={Frans A. Kuypers and Richard Alan Lewis and M Hua and Michael Schott and Dennis E Discher and Joel D Ernst and Bertram H. Lubin},
  journal={Blood},
  year={1996},
  volume={87 3},
  pages={1179-87}
}
The phospholipids of the human red cell are distributed asymmetrically in the bilayer of the red cell membrane. In certain pathologic states, such as sickle cell anemia, phospholipid asymmetry is altered. Although several methods can be used to measure phospholipid organization, small organizational changes have been very difficult to assess. Moreover, these methods fail to identify subpopulations of cells that have lost their normal phospholipid asymmetry. Using fluorescently labeled annexin V… CONTINUE READING

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Phospholipid asymmetry and diffusion in the membrane of normal and sickle erythrocytes

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Phospholipid asymmetry and diffusion in the membrane of normal and sickle erythrocytes, in Onishi S. (ed): Membrane Linked Diseases

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