Detection of alpha-globin gene disorders by a simple PCR methodology.

@article{Foglietta1996DetectionOA,
  title={Detection of alpha-globin gene disorders by a simple PCR methodology.},
  author={Enrica Foglietta and Giancarlo Deidda and B Graziani and Guido Modiano and Ida Bianco},
  journal={Haematologica},
  year={1996},
  volume={81 5},
  pages={
          387-96
        }
}
BACKGROUND alpha thalassemias are very common in all thalassemic areas; however, complete knowledge of the phenotypic, genotypic and epidemiological features of these thalassemias has not yet been achieved for a number of reasons: the frequent absence of a thalassemic hematologic picture, the lack of a specific characteristic comparable to the Hb A2 increase for beta thalassemias, and the almost complete homology between the two alpha genes. METHODS AND RESULTS A new set of PCR techniques… CONTINUE READING
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