Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging.

@article{Sun2005DetectionOA,
  title={Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging.},
  author={Shu-Wei Sun and Sheng-Kwei Song and Michael P. Harms and Shiow-Jiuan Lin and David M Holtzman and Kalpana M. Merchant and John J. Kotyk},
  journal={Experimental neurology},
  year={2005},
  volume={191 1},
  pages={77-85}
}
Using magnetic resonance diffusion tensor imaging (DTI), the present study investigates changes in both gray and white matter in the APPsw transgenic mouse (Tg2576), a model of beta-amyloid plaque deposition associated with Alzheimer's disease (AD). DTI analyses were performed in cross-sectional groups of transgene-positive and -negative mice at 8, 12, 16, and 18 months of age to assess the magnitude of water diffusion in gray matter (i.e., Tr(D)) and changes in diffusion in white matter that… CONTINUE READING
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