Detection of acrolein and crotonaldehyde DNA adducts in cultured human cells and canine peripheral blood lymphocytes by 32P-postlabeling and nucleotide chromatography.

@article{Wilson1991DetectionOA,
  title={Detection of acrolein and crotonaldehyde DNA adducts in cultured human cells and canine peripheral blood lymphocytes by 32P-postlabeling and nucleotide chromatography.},
  author={Vincent L. Wilson and Peter G. Foiles and F L Chung and Andrew C. Povey and Anthony A Frank and Curtis C. Harris},
  journal={Carcinogenesis},
  year={1991},
  volume={12 8},
  pages={1483-90}
}
People are constantly being exposed to toxic and carcinogenic aldehydes. However, little is actually known about the mechanisms underlying the toxic and carcinogenic effects of these aldehydes on human cells. The DNA alkylating activities of two of the more toxic and environmentally prominent alpha,beta-unsaturated aldehydes, acrolein and crotonaldehyde, have been studied utilizing 32P-postlabeling and nucleotide chromatographic techniques. Several putative adducts were observed in DNAs… CONTINUE READING

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