Detection of abnormal visual cortex in children with amblyopia by voxel-based morphometry.

@article{Xiao2007DetectionOA,
  title={Detection of abnormal visual cortex in children with amblyopia by voxel-based morphometry.},
  author={Jiangxi Xiao and Sheng Xie and Jin-tang Ye and Hai Hua Liu and Xiao Ling Gan and Gaolang Gong and Xue Xiang Jiang},
  journal={American journal of ophthalmology},
  year={2007},
  volume={143 3},
  pages={
          489-93
        }
}
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gonglab.bnu.edu.cn
44 Citations
Background Citations
6
Methods Citations
1
Results Citations
5

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44 Citations

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[Cerebral structural characteristics in children with unilateral amblyopia: a MRI study].
TLDR
The hypothesis that pathological ontogenetic processes in children with amblyopia lead to the structural abnormalities of the primary visual cortex is supported.
Grey and white matter changes in children with monocular amblyopia: voxel-based morphometry and diffusion tensor imaging study
TLDR
In monocular amblyopia, cortices related to spatial vision underwent volume loss, which provided neuroanatomical evidence of stereoscopic defects, and white matter development was also hindered due to visual defects in amblyopes.
Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study
TLDR
The use of the voxel-based morphometry technique to investigate structural alterations of the cerebral cortex in patients with strabismus and amblyopia might help to reveal the potential pathogenesis of SA and its relationship with the atrophy of specific regions of the brain.
Occipital lobe's cortical thinning in ametropic amblyopia.
Association of Optic Radiation Integrity with Cortical Thickness in Children with Anisometropic Amblyopia
TLDR
The findings indicate that developmental changes occur simultaneously in the OR and visual cortex in amblyopia, and provide key information on complex damage of brain networks in anisometropic Amblyopia.
Morphologic changes in the visual cortex of patients with anisometropic amblyopia: a surface-based morphometry study
TLDR
In addition to cortical thickness, the altered mean curvature of the cortex may indicate neuroanatomic impairments of the visual cortex in patients with anisometropic amblyopia.
Tract-based spatial statistics analysis of white matter changes in children with anisometropic amblyopia
Distinct patterns of spontaneous brain activity between children and adults with anisometropic amblyopia: a resting-state fMRI study
TLDR
Rs-fMRI is an effective noninvasive technique for exploring brain activity of the anisometropic amblyopia and demonstrated that brain activity changed both in amblyopic children and adults under the resting state, and revealed the differences in spontaneous activity patterns.
Enhanced Gray Matter Volume Compensates for Decreased Brain Activity in the Ocular Motor Area in Children with Anisometropic Amblyopia
TLDR
The findings may suggest that PAA patients experience structural and functional abnormalities in brain regions related to oculomotor and visual-spatial information, which reflects compensatory or neural plasticity in PAA Patients.
Altered spontaneous brain activity in patients with strabismic amblyopia: A resting-state fMRI study using regional homogeneity analysis
TLDR
The results of the present study suggested that visual information processing may be impaired in visual areas V1 and V2 and that adult patients with strabismic amblyopia exhibited brain plasticity that compensated for visuomotor coordination and visuospatial imagery deficits.
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References

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TLDR
MRI and psychophysical vision testing indicated that adults and children with amblyopia have decreased gray matter volume in visual cortical regions, including the calcarine sulcus, known to contain primary visual cortex.
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The results are consistent with the hypotheses that contrast thresholds are elevated in amblyopia because fewer neurons are responsive during amblyopic stimulation, and that the average firing rate of the responsive neurons, which reflects the perception of contrast, is unaffected in Amblyopia.
Voxel-Based Morphometry—The Methods
At its simplest, voxel-based morphometry (VBM) involves a voxel-wise comparison of the local concentration of gray matter between two groups of subjects. The procedure is relatively straightforward…
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