Detection of a specific isoform of alpha-actinin with antisera directed against dystrophin

  title={Detection of a specific isoform of alpha-actinin with antisera directed against dystrophin},
  author={Eric P. Hoffman and Simon C. Watkins and Henry S. Slayter and Louis M. Kunkel},
  journal={The Journal of Cell Biology},
  pages={503 - 510}
We have characterized a protein immunologically related to dystrophin, the protein product of the Duchenne muscular dystrophy gene. We identify this related protein as a fast-twitch glycolytic isoform (mouse extensor digitorum longus-specific) of myofibrillar alpha-actinin. This specific isoform of alpha-actinin exhibits a more restricted pattern of expression in skeletal muscle than fast-twitch-specific isoforms of both myosin and Ca2+-ATPase. Our results provide evidence that dystrophin and… CONTINUE READING
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Alpha - actinin - eontaining aggregates in transformed cells are highly dynamic structures . 3 "

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