Detection of a new hybrid α2 globin gene among American Blacks

@article{Gu2004DetectionOA,
  title={Detection of a new hybrid α2 globin gene among American Blacks},
  author={Yuan-chao Gu and Tadako Nakatsuji and T. H. Huisman},
  journal={Human Genetics},
  year={2004},
  volume={79},
  pages={68-72}
}
  • Yuan-chao Gu, Tadako Nakatsuji, T. H. Huisman
  • Published in Human Genetics 2004
  • Biology
  • SummaryWe have examined the α globin gene complex for 49 individuals with α-thalassemia-2 (−α3.7). Crossovers resulting in α-thalassemia-2 (type I) were observed in all 57 chromosomes with the −α3.7 defect. Except for one α-thalassemia-2 chromosome, all were linked to the absence of an Rsa I restriction site located 0.7 kb 5′ to the α2-globin gene; this polymorphic site was observed for 10 of 38 non-α-thalassemia chromosomes from Black Americans. In four Black families with a heterozygous… CONTINUE READING

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