Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes.

@article{Krogvold2015DetectionOA,
  title={Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes.},
  author={Lars Krogvold and Bj\orn Edwin and Trond A Buanes and Gun Frisk and Oskar Skog and Mahesh Anagandula and Olle Korsgren and Dag Erik Undlien and Morten Christoph Eike and Sarah J. Richardson and Pia Leete and Noel G Morgan and Sami Oikarinen and Maarit Oikarinen and Jutta E. Laiho and Heikki Hy{\"o}ty and Johnny Ludvigsson and Kristian Folkvord Hanssen and Knut Dahl-J\orgensen},
  journal={Diabetes},
  year={2015},
  volume={64 5},
  pages={1682-7}
}
The Diabetes Virus Detection study (DiViD) is the first to examine fresh pancreatic tissue at the diagnosis of type 1 diabetes for the presence of viruses. Minimal pancreatic tail resection was performed 3-9 weeks after onset of type 1 diabetes in six adult patients (age 24-35 years). The presence of enteroviral capsid protein 1 (VP1) and the expression of class I HLA were investigated by immunohistochemistry. Enterovirus RNA was analyzed from isolated pancreatic islets and from fresh-frozen… CONTINUE READING
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