Detection of a cytokeratin determinant common to diverse epithelial cells by a broadly cross-reacting monoclonal antibody.

@article{Gigi1982DetectionOA,
  title={Detection of a cytokeratin determinant common to diverse epithelial cells by a broadly cross-reacting monoclonal antibody.},
  author={O Gigi and Benjamin Geiger and Zelig Eshhar and Roland Moll and Erika Schmid and Stefanie Winter and Dorothea L. Schiller and Werner Franke},
  journal={The EMBO journal},
  year={1982},
  volume={1 11},
  pages={1429-37}
}
A monoclonal antibody derived from a mouse immunized with bovine epidermal prekeratin has been characterized by its binding to cytoskeletal polypeptides separated by one- or two-dimensional gel electrophoresis and by immunofluorescence microscopy. This antibody (KG 8.13) binds to a determinant present in a large number of human cytokeratin polypeptides, notably some polypeptides (Nos. 1, 5, 6, 7, and 8) of the 'basic cytokeratin subfamily' defined by peptide mapping, as well as a few acidic… CONTINUE READING