Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce

@article{Yez2013DetectionOA,
  title={Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce},
  author={A. Y{\'a}{\~n}ez and Nargess Hassanzadeh-Kiabi and M. Ng and J. Meg{\'i}as and Aparna Subramanian and George Y. Liu and D. Underhill and M. Gil and H. Goodridge},
  journal={European Journal of Immunology},
  year={2013},
  volume={43}
}
Several groups have shown that detection of microbial components by TLRs on hematopoietic stem and progenitor cells (HSPCs) instructs myeloid cell generation, raising interest in the possibility of targeting TLRs on HSPCs to boost myelopoiesis. However, although “TLR‐derived” cells exhibit myeloid cell characteristics (phagocytosis, cytokine production, antigen presentation), it is not clear whether they are functionally equivalent to macrophages derived in the absence of TLR activation. Our in… Expand
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