Detection of a Polyoma Virus-induced Tumor-associated Membrane Antigen in Mouse Cells by the Macrophage Migration Inhibition Test 1

Soluble membrane fractions derived from polyoma tumor cells trigger lymphocytes, derived from polyoma-immunized animals, but not from nonimmunized controls, to release the lymphokine, macrophage migra tion-inhibitory factor. The reaction can be blocked by sera from polyomabearing animals. Absorption of these sera with polyoma cells, but not with nonpolyoma… CONTINUE READING