Detection of Viruses Via Statistical Gene Expression Analysis

  title={Detection of Viruses Via Statistical Gene Expression Analysis},
  author={Minhua Chen and David E. Carlson and Aimee K. Zaas and Christopher W. Woods and Geoffrey S. Ginsburg and Alfred O. Hero and Joseph E. Lucas and Lawrence Carin},
  journal={IEEE Transactions on Biomedical Engineering},
We develop a new Bayesian construction of the elastic net (ENet), with variational Bayesian analysis. This modeling framework is motivated by analysis of gene expression data for viruses, with a focus on H3N2 and H1N1 influenza, as well as Rhino virus and RSV (respiratory syncytial virus). Our objective is to understand the biological pathways responsible for the host response to such viruses, with the ultimate objective of developing a clinical test to distinguish subjects infected by such… CONTINUE READING
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