Detection of T cells in paraffin wax embedded tissue using antibodies against a peptide sequence from the CD3 antigen.

@article{Mason1989DetectionOT,
  title={Detection of T cells in paraffin wax embedded tissue using antibodies against a peptide sequence from the CD3 antigen.},
  author={David Mason and Jacqueline L. Cordell and Marion H Brown and Gorm Pallesen and Elisabeth Methner Ralfkiaer and Jonathan B. Rothbard and Michael J. Crumpton and Kevin C. Gatter},
  journal={Journal of clinical pathology},
  year={1989},
  volume={42 11},
  pages={
          1194-200
        }
}
Rabbit polyclonal antibodies were raised against a proline rich, peptide sequence, comprising 13 amino acids, in the cytoplasmic domain of the CD3 epsilon chain. Immunoprecipitation experiments showed that this antibody preparation recognised the CD3 antigen on human T lymphoblasts. The antibody stained normal T cells strongly in tissue sections which had been fixed in formalin or Bouin's solution and embedded in paraffin wax. Its reactivity with T cell lymphoma, when evaluated on a series of… CONTINUE READING
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