Detection of Sulfatase Enzyme Activity with a CatalyCEST MRI Contrast Agent.

@article{Sinharay2016DetectionOS,
  title={Detection of Sulfatase Enzyme Activity with a CatalyCEST MRI Contrast Agent.},
  author={Sanhita Sinharay and Gabriela Fern{\'a}ndez-Cuervo and Jasmine P Acfalle and Mark D. Pagel},
  journal={Chemistry},
  year={2016},
  volume={22 19},
  pages={6491-5}
}
A chemical exchange saturation transfer (CEST) MRI contrast agent has been developed that detects sulfatase enzyme activity. The agent produces a CEST signal at δ=5.0 ppm before enzyme activity, and a second CEST signal appears at δ=9.0 ppm after the enzyme cleaves a sulfate group from the agent. The comparison of the two signals improved detection of… CONTINUE READING