Detection of Silicone Oil Leakages in Freeze Dryers

@article{Meissner2011DetectionOS,
  title={Detection of Silicone Oil Leakages in Freeze Dryers},
  author={U. Meissner and Harald Stahl and D. Steinkellner},
  journal={PDA Journal of Pharmaceutical Science and Technology},
  year={2011},
  volume={65},
  pages={481 - 485}
}
  • U. Meissner, Harald Stahl, D. Steinkellner
  • Published 2011
  • Medicine, Chemistry
  • PDA Journal of Pharmaceutical Science and Technology
  • As a small leakage from the silicone oil tubes in pharmaceutical freeze dryers may go undetected for several cycles, it provides a major threat to both product safety and the economic performance of such installations. A properly mounted mass spectrometer offers a non-invasive method of detecting the smallest amounts of silicone oil down to 1 ppm. Additionally the system will improve leak testing procedures and can also be used as a process analytical technology tool to improve process control… CONTINUE READING

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    References

    Publications referenced by this paper.
    NIST Chemistry WebBook; NIST (National Institute of Standards and Technology) Standard Reference