Detection of Sildenafil Analogues in Herbal Products for Erectile Dysfunction

@article{SzeYinOh2006DetectionOS,
  title={Detection of Sildenafil Analogues in Herbal Products for Erectile Dysfunction},
  author={Sharon Sze-Yin Oh and Peng Zou and Min-Yong Low and Hwee-Ling Koh},
  journal={Journal of Toxicology and Environmental Health, Part A},
  year={2006},
  volume={69},
  pages={1951 - 1958}
}
Sildenafil, the active ingredient in Viagra (Pfizer), is a prescription medicine used for erectile dysfunction. Compounds with chemical structures similar to that of sildenafil were isolated and purified during the analysis of some herbal products marketed for treatment of erectile dysfunction. Structural elucidation using liquid chromatography–diode array detection, infrared spectroscopy, liquid chromatography–tandem mass spectrometry, and nuclear magnetic resonance spectroscopy confirmed that… 
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TLDR
It is indicated for the treatment of male erectile dysfunction and previously unpublished data from the American Association of Poison Control Centers Toxic Exposure Surveillance System indicate that unintentional pediatric exposures to sildenafil are unlikely to be associated with adverse effects.
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TLDR
Researchers said sildenafil showed a positive impact on men with mild-tomoderate lower urinary tract symptoms andorized that themedication’s effect is mediated through bladder neck/ prostatic smooth muscle relaxation.
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Oral sildenafil is an effective, well-tolerated treatment for men with erectile dysfunction and is associated with improved erectile function in the dose-response study.
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TLDR
A new analogue of sildenafil was discovered to have been added illegally to a functional food marketed for penile erectile dysfunction, and an analytical method using HPLC was proposed.
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TLDR
A tadalafil analogue and hydroxyhomosildenafil were isolated from a herbal product marketed for erectile dysfunction and should be included as a target compound when screening for adulterants in herbal products.
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It is suggested that herbal weight loss aids are unsafe in some people because of the evidence for their efficacy and the clinical presentation of these 12 patients was consistent with hepatocellular-type or mixed-type liver injury.
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