Detection of SNP epistasis effects of quantitative traits using an extended Kempthorne model.

@article{Mao2006DetectionOS,
  title={Detection of SNP epistasis effects of quantitative traits using an extended Kempthorne model.},
  author={Yongcai Mao and Nicole R. London and Li Ma and Daniel Dvorkin and Yang Da},
  journal={Physiological genomics},
  year={2006},
  volume={28 1},
  pages={
          46-52
        }
}
Epistasis effects (gene interactions) have been increasingly recognized as important genetic factors underlying complex traits. The existence of a large number of single nucleotide polymorphisms (SNPs) provides opportunities and challenges to screen DNA variations affecting complex traits using a candidate gene analysis. In this article, four types of epistasis effects of two candidate gene SNPs with Hardy-Weinberg disequilibrium (HWD) and linkage disequilibrium (LD) are considered: additive x… 
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