Detection of Regulatory SNPs in Human Genome Using ChIP-seq ENCODE Data

@inproceedings{Bryzgalov2013DetectionOR,
  title={Detection of Regulatory SNPs in Human Genome Using ChIP-seq ENCODE Data},
  author={Leonid O. Bryzgalov and Elena V. Antontseva and Marina Yu. Matveeva and Alexander G. Shilov and Elena V. Kashina and Viatcheslav A. Mordvinov and Tatyana I. Merkulova},
  booktitle={PloS one},
  year={2013}
}
A vast amount of SNPs derived from genome-wide association studies are represented by non-coding ones, therefore exacerbating the need for effective identification of regulatory SNPs (rSNPs) among them. However, this task remains challenging since the regulatory part of the human genome is annotated much poorly as opposed to coding regions. Here we describe an approach aggregating the whole set of ENCODE ChIP-seq data in order to search for rSNPs, and provide the experimental evidence of its… CONTINUE READING

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