Detection of QTc interval prolongation using jacket telemetry in conscious non-human primates: comparison with implanted telemetry.

Abstract

BACKGROUND AND PURPOSE During repeat-dose toxicity studies, ECGs are collected from chemically or physically-restrained animals over a short timeframe. This is problematic due to cardiovascular changes caused by manual restraint stress and anesthesia, and limited ECG sampling. These factors confound data interpretation, but may be overcome by using a non… (More)
DOI: 10.1111/bph.12484

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